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Breast cancer

CALOR favours adjuvant therapy for ILRR of breast cancer

Nature Reviews Clinical Oncology volume 11, page 120 (2014)Cite this article

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Isolated local regional recurrence (ILRR) of breast cancer is often associated with a poor prognosis and a high risk of distant metastasis. To reduce the risk of further relapses and death, the recently published results from the CALOR trial recommend the use of adjuvant chemotherapy for those patients with breast cancer who have had complete resection of ILRR tumours

Stefan Aebi, one of the CALOR investigators, explains that “CALOR was a simple randomized clinical trial with two treatment arms, one with chemotherapy, the other without.” All patients in the trial had local therapy consisting of surgery and radiation therapy; they also received endocrine therapy if the tumours expressed oestrogen receptor (ER) or progesterone receptor (PR), and were offered HER2-directed therapy as required. He continues, “CALOR was pragmatic in the sense that oncologists could use any type of chemotherapy they considered useful based on prior therapies and on individual patient factors.”

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References

  1. Aebi, S. et al. Chemotherapy for isolated locoregional recurrence of breast cancer (CALOR): a randomised trial. Lancet Oncol. 10.1016/S1470-2045(13)70589-8

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Authors
  1. Alessia Errico
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Errico, A. CALOR favours adjuvant therapy for ILRR of breast cancer. Nat Rev Clin Oncol 11, 120 (2014). https://doi.org/10.1038/nrclinonc.2014.13

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  • DOI: https://doi.org/10.1038/nrclinonc.2014.13

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