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A clinical trial involves the study of the safety, efficacy and/or dosage regimen of a therapeutic intervention (such as a drug) in humans selected according to predetermined criteria of eligibility (such as a defined severity of a specific disease), who are observed for predefined evidence of favourable and unfavourable effects.
Despite mixed efficacy outcomes, a phase 1/2 umbrella trial brings the glioblastoma field closer to a new era of diagnostic precision and targeted therapy.
An expert recommendation is presented for the design and evaluation of research studies using transcranial electrical stimulation, resulting in the selection of a 66-point checklist aimed at improving the quality of transcranial electrical stimulation studies.
Patients with obesity achieved significant weight loss and cardiometabolic benefits with oral orforglipron — offering a potential alternative to injectable GLP-1 receptor agonists.
Despite mixed efficacy outcomes, a phase 1/2 umbrella trial brings the glioblastoma field closer to a new era of diagnostic precision and targeted therapy.
Offering free-of-charge in-hospital influenza vaccination improves survival and reduces changes of readmission in patients with advanced heart failure, according to a large cluster-randomized trial across hospitals in China.
A prospective implementation study shows how a low-cost, swallowable capsule sponge could be used for regular monitoring and risk stratification in people with Barrett’s esophagus, offering a minimally invasive alternative to endoscopy.
The anti-fibrotic and anti-inflammatory agent nerandomilast has shown promise for the treatment of both idiopathic and progressive pulmonary fibrosis in phase III trials.
