Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • In Brief
  • Published:

Skin cancer

DT01 DNA-repair inhibitor shows promise

Nature Reviews Clinical Oncology volume 13, page 396 (2016)Cite this article

Subjects

Access through your institution
Buy or subscribe

A number of therapies have been approved for patients with metastatic melanoma, but responses are often limited and mortality remains high; therefore, new therapeutic options are needed. In a phase I trial, a novel DNA-repair inhibitor, DT01, was evaluated in 23 patients with melanoma skin metastases. DT01 is an injectable oligonucleotide mimic of DNA lesions that sequesters the DNA-repair machinery from lesions in genomic DNA. Thus, DT01 was used in combination with radiotherapy to induce genomic lesions. Dose escalation revealed no dose-limiting toxicities after intratumoural and peritumoural injection of DT01, and a maximum tolerated dose was not reached; grade 1–2 injection-site reactions were the most common adverse events. Evaluation of efficacy at 76 lesions in 21 patients revealed promising objective and complete response rates of 59% and 30%, respectively.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Le Tourneau, C. et al. First-in-human phase I study of the DNA-repair inhibitor DT01 in combination with radiotherapy in patients with skin metastases from melanoma. Br. J. Cancer http://dx.doi.org/10.1038/bjc.2016.120 (2016)

Download references

Authors
  1. David Killock
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Killock, D. DT01 DNA-repair inhibitor shows promise. Nat Rev Clin Oncol 13, 396 (2016). https://doi.org/10.1038/nrclinonc.2016.86

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrclinonc.2016.86

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing