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Obesity

Obesity alters fatty acid sensing

Nature Reviews Endocrinology volume 13, page 65 (2017)Cite this article

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A growing body of evidence suggests that the capacity of the intestine to sense fatty acids is compromised in obesity. In new research, investigators have found that the intestinal expression of genes that encode three free fatty acid sensors, FFAR1, FFAR4 and CD36, are significantly altered in humans with obesity.

The investigators, recruited individuals who were lean, overweight or with obesity and took biopsy samples from the duodenum before and after a 30-minute infusion of lipids.

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References

  1. Cvijanovic, N. et al. Lipid stimulation of fatty acid sensors in the human duodenum: relationship with gastrointestinal hormones, BMI and diet. Int. J. Obesity http://dx.doi.org/10.1038/ijo.2016.199 (2016)

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  1. Tim Geach
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Geach, T. Obesity alters fatty acid sensing. Nat Rev Endocrinol 13, 65 (2017). https://doi.org/10.1038/nrendo.2016.214

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