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Diabetes

Insulitic profiles in T1DM

Nature Reviews Endocrinology volume 12, page 187 (2016)Cite this article

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Insulitis, the infiltration of lymphocytes and consequent inflammation of pancreatic islets, was thought to occur in a fairly uniform manner in type 1 diabetes mellitus (T1DM). However, a newly-identified feature in the lymphocyte-specific profile of insulitis might change our understanding of the disease.

The investigators, reporting in Diabetes, found that patients with new-onset T1DM had variable numbers of CD20+ B lymphocytes in pancreatic islets, called CD20Hi and CD20Lo, which corresponded to the age of disease onset. Those individuals diagnosed with T1DM before the age of 7 years had a ratio of CD20+ to CD4+ cells greater than one (CD20Hi); those diagnosed after the age of 13 years had a ratio of CD20+ to CD4+ less than one (CD20Lo). Cytotoxic CD8+ cells were present, regardless of the number of CD20+ cells.

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References

  1. Leete, P. et al. Differential insulitic profiles determine the extent of beta cell destruction and the age at onset of type 1 diabetes. Diabetes http://dx.doi.org/10.2337/db15-1615

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Authors
  1. Tim Geach
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Cite this article

Geach, T. Insulitic profiles in T1DM. Nat Rev Endocrinol 12, 187 (2016). https://doi.org/10.1038/nrendo.2016.31

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  • DOI: https://doi.org/10.1038/nrendo.2016.31

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