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Folate status and genetic selection

Nature Reviews Genetics volume 6, page 248 (2005)Cite this article

A Correspondence to this article was published on 01 March 2005

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We read the recent Review by Lucock and Yates with interest1. The authors postulate that improved folate nutrition either through periconceptional supplementation with folic acid or through mandatory fortification of foodstuffs is exerting a strong selective pressure on the MTHFR 677C>T polymorphic variant.

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References

  1. Lucock, M. & Yates, Z. Folic acid — vitamin and panacea or genetic time bomb? Nature Rev. Genet. 6, 235–240 (2005).

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Authors and Affiliations

  1. Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences, University of Newcastle, United Kingdom

    Caroline L. Relton & Mark S. Pearce

  2. Department of Social Medicine, University of Bristol, United Kingdom

    Andrew Ness

  3. Institute of Human Genetics, University of Newcastle,

    John Burn

Authors
  1. Caroline L. Relton
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  2. Mark S. Pearce
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  3. Andrew Ness
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  4. John Burn
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Relton, C., Pearce, M., Ness, A. et al. Folate status and genetic selection. Nat Rev Genet 6, 248 (2005). https://doi.org/10.1038/nrg1558-c1

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