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Bioengineered internal anal sphincter constructs successfully implanted into mice

Nature Reviews Gastroenterology & Hepatology volume 7, page 534 (2010)Cite this article

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The IAS is vital for maintaining rectoanal continence. Damage or dysfunction of the IAS can cause fecal incontinence, and the currently available treatment options in these cases produce limited results.

“The [ongoing] aim of this project is to bioengineer a three-dimensional IAS as a treatment for anal incontinence,” explains Khalil N. Bitar, corresponding author of the study. “Generation of tissue-engineered replacement organs by extracting cells from patients, growing them outside the human body and re-introduction into the body represents an ideal source for corrective treatment.”

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ORIGINAL RESEARCH PAPER

  1. Raghavan, S. et al. Successful implantation of physiologically functional bioengineered mouse internal anal sphincter. Am. J. Physiol. Gastrointest. Liver Physiol. 299, 430–439 (2010)

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  1. Isobel Franks
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Franks, I. Bioengineered internal anal sphincter constructs successfully implanted into mice. Nat Rev Gastroenterol Hepatol 7, 534 (2010). https://doi.org/10.1038/nrgastro.2010.144

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  • DOI: https://doi.org/10.1038/nrgastro.2010.144

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