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Esophagus

Eosinophilic esophagitis—mast cells, B cells and IgE production

Nature Reviews Gastroenterology & Hepatology volume 7, page 124 (2010)Cite this article

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Eosinophilic esophagitis (EE)—a chronic inflammatory disorder of the esophagus—is considered an atopic disease, but its pathogenesis is poorly understood.

The esophagus has only recently been recognized as an immunologically active tissue. Marc Rothenberg and colleagues from the Cincinnati Children's Hospital Medical Center investigated the production of IgE and levels of B cells and mast cells in the esophagi of patients with EE. “Based on the limited value of skin-prick testing for food allergies (even though EE is a food allergy problem) we hypothesized that the local generation of immunoglobulin (specifically allergy types) could be occurring and that these could be directly and locally sensitizing mast cells,” says Rothenberg.

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ORIGINAL RESEARCH PAPERS

  1. Vicario, M. et al. Local B cells and IgE production in the oesophageal mucosa in eosinophilc oesophagitis. Gut 59, 12–20 (2009)

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Authors
  1. Isobel Franks
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Franks, I. Eosinophilic esophagitis—mast cells, B cells and IgE production. Nat Rev Gastroenterol Hepatol 7, 124 (2010). https://doi.org/10.1038/nrgastro.2010.17

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  • DOI: https://doi.org/10.1038/nrgastro.2010.17

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