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Crohn's disease

Soluble plant fibers may protect against E. coli translocation

Nature Reviews Gastroenterology & Hepatology volume 7, page 650 (2010)Cite this article

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These researchers have assessed the effects of various soluble plant fibers and food emulsifiers on the translocation of Crohn's-disease-associated Escherichia coli isolates across specialized microfold (M) cells of the gut epithelium.

The initial sites of inflammation in Crohn's disease usually overlie Peyer's patches and lymphoid follicles of the colon. There is evidence that bacteria (known to be important in the pathogenesis of IBD) are able to invade the gut epithelium via M cells that are located at these sites. “The incidence of Crohn's disease has been increasing worldwide and diet is believed to be linked to its higher prevalence in industrialized parts of the world,” explains Campbell. “So we were interested to see if key dietary factors could modify Crohn's E. coli entry through the gut epithelium.”

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ORIGINAL RESEARCH PAPER

  1. Roberts, C. L. et al. Translocation of Crohn's disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers. Gut 59, 1331–1339 (2010)

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  1. Isobel Franks
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Franks, I. Soluble plant fibers may protect against E. coli translocation. Nat Rev Gastroenterol Hepatol 7, 650 (2010). https://doi.org/10.1038/nrgastro.2010.180

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  • DOI: https://doi.org/10.1038/nrgastro.2010.180

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