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Transplantation

Functional ectopic liver tissue in the lymph nodes of mice with lethal liver disease

Nature Reviews Gastroenterology & Hepatology volume 8, page 182 (2011)Cite this article

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Previous animal studies have investigated the possibility of hepatocyte transplantation into extrahepatic sites, but with variable results. Eric Lagasse and colleagues decided to investigate whether functional ectopic liver tissue could be developed in the lymph nodes.

Hepatocytes were transplanted by intraperitoneal injection into fumarylacetoacetate hydrolase (Fah−/−) mice, a model of the human liver disease tyrosinemia type I. 10 weeks after transplantation, these mice demonstrated improvements in their serum levels of aminotransferases, bilirubin and amino acids. Expansion of hepatocytes rescued the mice from lethal hepatic failure.

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ORIGINAL RESEARCH PAPER

  1. Hoppo, T. et al. Rescue of lethal hepatic failure by hepatized lymph nodes in mice. Gastroenterology 140, 656–666 (2011)

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Authors
  1. Isobel Franks
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Franks, I. Functional ectopic liver tissue in the lymph nodes of mice with lethal liver disease. Nat Rev Gastroenterol Hepatol 8, 182 (2011). https://doi.org/10.1038/nrgastro.2011.25

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  • DOI: https://doi.org/10.1038/nrgastro.2011.25

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