Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Biopsy and personalized medicine

Nature Reviews Gastroenterology & Hepatology volume 9, page 683 (2012)Cite this article

Subjects

Access through your institution
Buy or subscribe

As the function of biopsy continues to expand beyond diagnosis to facilitate improved accuracy of prognosis, metabolomics and tumour susceptibility to drugs, and to facilitate drug discovery for personalized medicine, fusion-guided biopsy using multiple imaging modalities of improved accuracy could prove critical to medical oncologists as they seek to unearth biology from imaging.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Fusion-guided biopsy for accurate image-to-tissue correlation.

References

  1. Whitcomb, D. C. What is personalized medicine and what should it replace? Nat. Rev. Gastroenterol. Hepatol. 9, 418–424 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Krücker, J. et al. Electromagnetic tracking for thermal ablation and biopsy guidance: clinical evaluation of spatial accuracy. J. Vasc. Interv. Radiol. 18, 1141–1150 (2007).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Kruecker, J. et al. Clinical utility of real-time fusion guidance for biopsy and ablation. J. Vasc. Interv. Radiol. 22, 515–524 (2011).

    Article  Google Scholar 

  4. Pinto, P. A. et al. Magnetic resonance imaging/ultrasound fusion guided prostate biopsy improves cancer detection following transrectal ultrasound biopsy and correlates with multiparametric magnetic resonance imaging. J. Urol. 186, 1281–1285 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Venkatesan, A. M. et al. Real-time FDG PET guidance during biopsies and radiofrequency ablation using multimodality fusion with electromagnetic navigation. Radiology 260, 848–856 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Abi-Jaoudeh, N. et al. Cone-beam computed tomography fusion and navigation for real-time positron emission tomography-guided biopsies and ablations: a feasibility study. J. Vasc. Interv. Radiol. 23, 737–743 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Posadas, E. M. et al. A phase II and pharmacodynamic study of gefitinib in patients with refractory or recurrent epithelial ovarian cancer. Cancer 109, 1323–1330 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Annunziata, C. M. et al. Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2. Clin. Cancer Res. 16, 664–672 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Rutman, A. M. & Kuo, M. D. Radiogenomics: creating a link between molecular diagnostics and diagnostic imaging. Eur. J. Radiol. 70, 232–241 (2009).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors would like to acknowledge the support of the Center for Interventional Oncology & the Intramural Research Program of the National Institutes of Health, NIH and Philips Healthcare.

Author information

Authors and Affiliations

  1. Center for Interventional Oncology, MSC 1182, National Institutes of Health, Bethesda, 20892, MD, USA

    Hayet Amalou & Bradford J. Wood

Authors
  1. Hayet Amalou
    View author publications

    Search author on:PubMed Google Scholar

  2. Bradford J. Wood
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Bradford J. Wood.

Ethics declarations

Competing interests

B. J. Wood has received grant/research support from Philips Healthcare.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Amalou, H., Wood, B. Biopsy and personalized medicine. Nat Rev Gastroenterol Hepatol 9, 683 (2012). https://doi.org/10.1038/nrgastro.2012.100-c1

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrgastro.2012.100-c1

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer