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Dyspepsia

Psychological factors in functional dyspepsia—keeping an open mind

Nature Reviews Gastroenterology & Hepatology volume 9, page 488 (2012)Cite this article

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A recent study provides evidence that various psychological factors and disturbances in gastric sensorimotor function are associated with different symptom-based subgroups in patients with functional dyspepsia.

According to the Rome III classification, functional dyspepsia can be subdivided into three symptom-based subgroups: postprandial distress syndrome (PDS); nausea and/or vomiting; and epigastric pain syndrome (EPS). “There is controversy in the literature regarding the association of symptom-based subgroups and psychopathology, somatization and gastric sensorimotor function (that is, gastric hypersensitivity and delayed gastric emptying),” says Lukas Van Oudenhove. Previous studies have suggested that gastric sensitivity, psychopathology and somatization are associated with EPS symptoms, and delayed gastric emptying is associated with PDS symptoms. However, another study showed that psychopathology was associated with a diagnosis of PDS.

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ORIGINAL RESEARCH PAPER

  1. Clauwaert, N. et al. Associations between gastric sensorimotor function, depression, somatization, and symptom-based subgroups in functional gastroduodenal disorders: are all symptoms equal? Neurogastroenterol. Motil. doi:10.1111/j.1365-2982.2012.01985.x

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  1. Isobel Franks
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Franks, I. Psychological factors in functional dyspepsia—keeping an open mind. Nat Rev Gastroenterol Hepatol 9, 488 (2012). https://doi.org/10.1038/nrgastro.2012.154

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  • DOI: https://doi.org/10.1038/nrgastro.2012.154

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