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Hepatitis

HCV virologic response—new nomenclature recommendations

As new therapeutics are emerging for the treatment of patients with HCV, the nomenclature for defining virologic response is becoming outdated, leading to inconsistencies and confusion. A recent paper has attempted to devise a new nomenclature that will be able to respond to future advances in HCV therapy.

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References

  1. European Association of the Study of the Liver. 2011 European Association of the Study of the Liver hepatitis C virus clinical practice guidelines. Liver Int. 32 (Suppl. 1), 2–8 (2012).

  2. McHutchison, J. G. et al. Peginterferon α-2b or α-2a with ribavirin for treatment of hepatitis C infection. N. Engl. J. Med. 361, 580–593 (2009).

    Article  CAS  Google Scholar 

  3. Mallet, V. et al. Brief communication: the relationship of regression of cirrhosis to outcome in chronic hepatitis C. Ann. Int. Med. 149, 399–403 (2008).

    Article  Google Scholar 

  4. McHutchison, J. G. et al. Telaprevir for previously treated chronic HCV infection. N. Engl. J. Med. 362, 1292–1303 (2010).

    Article  CAS  Google Scholar 

  5. Zeuzem, S. et al. Telaprevir for retreatment of HCV infection. N. Engl. J. Med. 364, 2417–2428 (2011).

    Article  CAS  Google Scholar 

  6. Bacon, B. R. et al. Boceprevir for previously treated chronic HCV genotype 1 infection. N. Engl. J. Med. 364, 1207–1217 (2011).

    Article  CAS  Google Scholar 

  7. Jacobson, I. M. et al. Telaprevir for previously untreated chronic hepatitis C virus infection. N. Engl. J. Med. 364, 2405–2416 (2011).

    Article  CAS  Google Scholar 

  8. Lok, A. S. et al. Preliminary study of two antiviral agents for hepatitis C genotype 1. N. Engl. J. Med. 366, 216–224 (2012).

    Article  CAS  Google Scholar 

  9. Gane, E. J. et al. Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet 376, 1467–1475 (2010).

    Article  CAS  Google Scholar 

  10. Wedemeyer, H. et al. Recommendations for standardized nomenclature and definitions of viral response in trials of HCV investigational agents. Hepatology http://dx.doi.org/10.1002/hep.25888.

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Acknowledgements

The author would like to thank Dr Matthew Albert for his help in the discussion of the manuscript.

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S. Pol has been a speaker and received grant/research support from BMS, Gilead, Roche and MSD. He has been a consultant and speaker for Janssen-Tibotec. S. Pol has been a speaker for Boehringer Ingelheim, Sanofi, Novartis and Vertex.

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Pol, S. HCV virologic response—new nomenclature recommendations. Nat Rev Gastroenterol Hepatol 9, 619–620 (2012). https://doi.org/10.1038/nrgastro.2012.164

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