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Potential of siRNA-based therapies for pancreatic fibrosis

Nature Reviews Gastroenterology & Hepatology volume 10, page 3 (2013)Cite this article

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Fibrosis associated with chronic pancreatitis is irreversible; no targeted therapies are currently available. Now, a new study published in Gut shows that an siRNA-based antifibrotic targeted therapy resolves pancreatic fibrosis in a rat model, offering hope for future antifibrotic drugs that can reverse this pancreatic damage.

In vitro studies confirmed specific uptake of VA-lip-siRNAgp46 into activated PSCs and knockdown of gp46, with subsequent suppression of collagen secretion. Using a rat model of chronic pancreatitis (induced by dibutyltin dichloride), the researchers confirmed specific delivery of VA-lip-siRNAgp46 directly to PSCs in fibrotic tissue in vivo. Moreover, 10 systemic treatments of VA-lip-siRNAgp46 (0.75 mg/kg siRNA) led to complete resolution of pancreatic fibrosis.

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ORIGINAL RESEARCH PAPER

  1. Ishiwatari, H. et al. Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitamin A-coupled liposomes. Gut doi:10.1136/gutjnl-2011-301746

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  1. Katrina Ray
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Ray, K. Potential of siRNA-based therapies for pancreatic fibrosis. Nat Rev Gastroenterol Hepatol 10, 3 (2013). https://doi.org/10.1038/nrgastro.2012.237

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