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Barrett oesophagus

PPIs might reduce risk of neoplastic progression in Barrett oesophagus

Nature Reviews Gastroenterology & Hepatology volume 10, page 66 (2013)Cite this article

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PPIs have become a mainstay of treatment in patients with Barrett oesophagus. Whether PPIs reduce the risk of neoplastic progression in these patients, however, was unclear; concerns had also been raised about the costs and potential adverse effects of prolonged PPI use. New findings, published in Clinical Gastroenterology and Hepatology, have now provided clinical evidence that prolonged use of PPIs in patients with Barrett oesophagus is justified.

Florine Kastelein and co-workers conducted a multicentre study of 540 patients with histologically proven Barrett oesophagus. Information on medication use was collected and correlated with the incidence of high-grade dysplasia and oesophageal adenocarcinoma during a median follow-up period of 5.2 years.

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ORIGINAL RESEARCH PAPER

  1. Kastelein, F. et al. Proton pump inhibitors reduce the risk of neoplastic progression in patients with Barrett's esophagus Clin. Gastroenterol. Hepatol. doi:10.1016/j.cgh.2012.11.014

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  1. Katherine Smith
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Smith, K. PPIs might reduce risk of neoplastic progression in Barrett oesophagus. Nat Rev Gastroenterol Hepatol 10, 66 (2013). https://doi.org/10.1038/nrgastro.2012.251

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