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Optimizing vaccination strategies against HBV in patients with IBD

Nature Reviews Gastroenterology & Hepatology volume 9, page 304 (2012)Cite this article

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A study published in Alimentary Pharmacology and Therapeutics shows that, in patients with IBD, administration of a double dose of HBV vaccine markedly increases the response rate compared with the standard dose.

“Little is known about the efficacy of standard HBV vaccination in patients with IBD, although it does seem to be quite low,” explains Javier Gisbert, one of the authors of the study. This situation is not ideal, as reactivation of HBV infection is an important concern in patients taking immunosuppressants (which includes many patients with IBD), as it can lead to fulminant hepatic failure and even death.

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ORIGINAL RESEARCH PAPER

  1. Gisbert, J. P. et al. Comparison of the effectiveness of two protocols for vaccination (standard and double dosage) against hepatitis B virus in patients with inflammatory bowel disease. Aliment. Pharmacol. Ther. doi:10.1111/j.1365-2036.2012.05110.x

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Authors
  1. Isobel Franks
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Franks, I. Optimizing vaccination strategies against HBV in patients with IBD. Nat Rev Gastroenterol Hepatol 9, 304 (2012). https://doi.org/10.1038/nrgastro.2012.94

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  • DOI: https://doi.org/10.1038/nrgastro.2012.94

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