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Biliary tract

IL-33, innate lymphoid cells and IL-13 are required for cholangiocyte proliferation

Nature Reviews Gastroenterology & Hepatology volume 11, page 456 (2014)Cite this article

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“Previous analyses of the hepatic transcriptome showed increased expression of IL-33 and its receptor in the livers of children at the time of diagnosis of biliary atresia,” says Jorge Bezerra, corresponding author of the study. “Therefore, we began studies to investigate the biological relevance of IL-33 to the biliary system in health and disease.”

Blocking the IL-33 receptor, ST2, with injections of an anti-ST2 antibody in a mouse model of biliary injury caused diffuse loss of epithelium compared with mice injected with IgG isotype antibodies. To determine if IL-33 is involved in cholangiocyte proliferation, IL-33 was injected into adult mice, which led to a 76-fold increase in proliferating cholangiocytes in extrahepatic bile ducts compared with control mice not receiving IL-33. These data demonstrate that IL-33–ST2 signalling is involved in cholangiocyte proliferation.

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References

  1. Li, J. et al. Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation. J. Clin. Invest. 10.1172/JCI73742

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Authors
  1. Gillian Patman
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Cite this article

Patman, G. IL-33, innate lymphoid cells and IL-13 are required for cholangiocyte proliferation. Nat Rev Gastroenterol Hepatol 11, 456 (2014). https://doi.org/10.1038/nrgastro.2014.101

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