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Infectious disease

HIV therapy good for HCV infection

Nature Reviews Gastroenterology & Hepatology volume 11, page 517 (2014)Cite this article

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Temporary increases in HCV RNA and alanine aminotransferase (ALT) levels do not negate the overall beneficial effects of HIV therapy for HCV infection, according to new research. The clinical trial was set up to evaluate the effect of initiation of combination antiretroviral therapy (cART) on HCV replication and liver injury in patients with HIV and HCV co-infection.

A subset of patients (4 of 17) had an HCV RNA 'flare' (defined as >0.5 log10 increase in HCV RNA from baseline) between 8–12 weeks of treatment and 82% of patients had a spike in HCV RNA levels at one or more time points during cART. However, the overall trend was a decline in HCV RNA levels by week 72 (of a 96-week treatment period).

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References

  1. Sherman, K. E. et al. Modulation of HCV replication after combination antiretroviral therapy in HCV/HIV co-infected patients. Sci. Transl. Med. 6, 246ra98 (2014)

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  1. Gillian Patman
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Patman, G. HIV therapy good for HCV infection. Nat Rev Gastroenterol Hepatol 11, 517 (2014). https://doi.org/10.1038/nrgastro.2014.145

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