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IBS

Jejunal humoral immunity in diarrhoea-predominant IBS

Nature Reviews Gastroenterology & Hepatology volume 11, page 643 (2014)Cite this article

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A study published in Gut has shown that jejunal tissue from patients with diarrhoea-predominant IBS (IBS-D) has higher numbers and activation of B cells and more cells positive for IgG than jejunal tissue from healthy people. In addition, the density of cells positive for IgG antibodies is associated with the number of daily bowel movements.

As little is known about the immune dysfunction involved in IBS, “we designed this study to clarify the participation and role of locally released immunoglobulins,” says corresponding author Maria Vicario.

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References

  1. Vicario, M. et al. Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associated with clinical manifestations. Gut 10.1136/gutjnl-2013-306236

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Authors
  1. Gillian Patman
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Patman, G. Jejunal humoral immunity in diarrhoea-predominant IBS. Nat Rev Gastroenterol Hepatol 11, 643 (2014). https://doi.org/10.1038/nrgastro.2014.169

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  • DOI: https://doi.org/10.1038/nrgastro.2014.169

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