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Regenerative medicine

Knocking on the door to successful hepatocyte transplantation

Nature Reviews Gastroenterology & Hepatology volume 11, pages 277–278 (2014)Cite this article

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With the ongoing shortage of livers available for transplantation, attention has turned to cell-based approaches to support liver function and enable liver regeneration. However, hepatocyte transplantation is beset with problems and a clinically adoptable strategy is lacking. How can a plentiful supply of hepatocyte-like cells with long-term proliferation be generated?

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Figure 1: Stepwise iMPC-Hep generation.

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Authors and Affiliations

  1. MRC Centre for Regenerative Medicine, Scottish Centre for Regenerative Medicine, 5 Little France Drive, Edinburgh, EH16 4UU, UK

    Stuart J. Forbes

  2. Centre for Tumour Biology, Barts and The London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK

    Malcolm R. Alison

Authors
  1. Stuart J. Forbes
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  2. Malcolm R. Alison
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Correspondence to Stuart J. Forbes.

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The authors declare no competing financial interests.

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Forbes, S., Alison, M. Knocking on the door to successful hepatocyte transplantation. Nat Rev Gastroenterol Hepatol 11, 277–278 (2014). https://doi.org/10.1038/nrgastro.2014.44

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