Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Pancreatic cancer

From normal to metastases—a whole gamut of pancreatic organoids

Nature Reviews Gastroenterology & Hepatology volume 12, page 61 (2015)Cite this article

Subjects

Progress in the early detection and treatment of pancreatic cancer has so far been hampered by the lack of relevant and tractable experimental model systems, according to Professor David Tuveson. A transatlantic collaboration between Tuveson and Professor Hans Clevers' groups published in Cell describes the development of pancreatic organoids covering normal, premalignant and malignant stages of cancer progression. Subsequent genetic and protein profiling revealed new leads on cancer biomarkers.

Organoid models are 3D in vitro culture systems that are reported to bridge the gap in preclinical research between simplistic 2D in vitro culture models and time-consuming and costly xenograft or genetically engineered mouse models. “Therefore, we sought to create a new [organoid] model system that would facilitate advances in our ability to diagnose and treat patients with pancreatic cancer,” explains Clevers.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Boj, S. F. et al. Organoid models of human and mouse ductal pancreatic cancer. Cell 10.1016/j.cell.2014.12.021

Download references

Authors
  1. Gillian Patman
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Patman, G. From normal to metastases—a whole gamut of pancreatic organoids. Nat Rev Gastroenterol Hepatol 12, 61 (2015). https://doi.org/10.1038/nrgastro.2015.1

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrgastro.2015.1

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing