Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Biliary tract

Solving the conundrum of cholangiocyte differentiation

Nature Reviews Gastroenterology & Hepatology volume 12, page 490 (2015)Cite this article

Subjects

Two new papers published in Nature Biotechnology have described methods for generating cholangiocyte organoids from human pluripotent stem cells.

Biliary diseases account for a substantial proportion of liver transplantations in adults and children, but the progress in developing new therapies has been hampered by a lack of research tools, namely, cell lines and animal models.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Sampaziotis, F. et al. Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation. Nat. Biotechnol. 10.1038/nbt.3275

  2. Ogawa, M. et al. Directed differentiation of cholangiocytes from human pluripotent stem cells. Nat. Biotechnol. 10.1038/nbt.3294

Download references

Authors
  1. Gillian Patman
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Patman, G. Solving the conundrum of cholangiocyte differentiation. Nat Rev Gastroenterol Hepatol 12, 490 (2015). https://doi.org/10.1038/nrgastro.2015.129

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrgastro.2015.129

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing