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CX3CR1—a direct line to gut–liver crosstalk?

Nature Reviews Gastroenterology & Hepatology volume 12, page 490 (2015)Cite this article

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Deleting CX3C chemokine receptor 1 (Cx3cr1) negatively affects intestinal barrier function and exacerbates steatohepatitis in a mouse model NASH, according to a study from Christian Trautwein's group published in Hepatology.

“The observation that patients suffering from IBD often also present elevated liver transaminases and show signs of mild steatohepatitis, caught our interest into how the immunological status of the intestine influences the liver,” explains first author Markus Schneider. CX3CR1 has previously been shown to have a role in both the liver and intestines, and so the authors hypothesized that it might also have a role in gut–liver crosstalk.

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References

  1. Schneider, K. M. et al. CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: limiting steatohepatits by maintaining intestinal homeostasis. Hepatology 10.1002/hep.27982

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  1. Gillian Patman
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Patman, G. CX3CR1—a direct line to gut–liver crosstalk?. Nat Rev Gastroenterol Hepatol 12, 490 (2015). https://doi.org/10.1038/nrgastro.2015.133

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