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Diabetes

Circulating factors implicated in diabetic enteropathy

Nature Reviews Gastroenterology & Hepatology volume 12, page 671 (2015)Cite this article

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According to new results published in Cell Stem Cell, altered levels of circulating serum factors in patients with type 1 diabetes mellitus (T1DM) results in abnormal intestinal mucosa morphology. The survival of colonic stem cells (CoSCs) was negatively affected by decreased levels of insulin-like growth factor 1 (IGF-1) and increased levels of insulin-like growth factor binding protein 3 (IGFBP-3).

Diabetic enteropathy affects up to 70% of patients with T1DM, but the underlying mechanisms are poorly defined. However, intestinal homeostasis is dependent on the proliferation and differentiation of CoSCs, located in the intestinal crypts. “We aimed to unveil the mechanisms behind diabetic enteropathy development and whether stem cells and circulating factors were somehow involved,” explains corresponding author Paolo Fiorina.

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References

  1. D'Addio, F. et al. Circulating IGF-I and IGFBP3 levels control human colonic stem cell function and are disrupted in diabetic enteropathy. Cell Stem Cell 10.1016/j.stem.2015.07.010

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  1. Hugh Thomas
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Thomas, H. Circulating factors implicated in diabetic enteropathy. Nat Rev Gastroenterol Hepatol 12, 671 (2015). https://doi.org/10.1038/nrgastro.2015.183

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  • DOI: https://doi.org/10.1038/nrgastro.2015.183

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