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Hepatocellular carcinoma

Ectopic lymphoid structures promote carcinogenesis in the liver

Nature Reviews Gastroenterology & Hepatology volume 12, page 671 (2015)Cite this article

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In many solid tumours, the presence of ectopic lymphoid structures (ELSs) is associated with a better prognosis, but the opposite scenario arises for hepatocellular carcinoma (HCC) according to new data.

ELSs are organized clusters of leukocytes resembling secondary lymphoid organs, which infiltrate tissues often at sites of inflammation. “While ELSs are very commonly seen in certain samples, we know very little about how they are formed and how they affect immune responses,” says one of the investigators Eli Pikarsky.

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References

  1. Finkin, S. et al. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat. Immunol. doi:10.1038/ni.3290

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  1. Gillian Patman
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Patman, G. Ectopic lymphoid structures promote carcinogenesis in the liver. Nat Rev Gastroenterol Hepatol 12, 671 (2015). https://doi.org/10.1038/nrgastro.2015.192

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