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Stem cells

IL-22 activates ISCs for intestinal regeneration

Nature Reviews Gastroenterology & Hepatology volume 13, page 64 (2016)Cite this article

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The immune system is able to regulate intestinal regeneration by acting directly on intestinal stem cells (ISC), according to new research published in Nature. The findings demonstrate that IL-22 promotes ISC-mediated intestinal epithelial regeneration in organoid models.

...there is not as much understanding related to how ISCs are regulated after tissue injury...

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References

  1. Lindemans, C. A. et al. Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. Nature http://dx.doi.org/10.1038/nature16460

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  1. Katrina Ray
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Ray, K. IL-22 activates ISCs for intestinal regeneration. Nat Rev Gastroenterol Hepatol 13, 64 (2016). https://doi.org/10.1038/nrgastro.2015.221

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