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Liver

Lipocalin 2 and steatohepatitis

Nature Reviews Gastroenterology & Hepatology volume 13, page 62 (2016)Cite this article

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Lipocalin 2 is a protein involved in innate immunity and protects against bacterial infection. However, according to results published in the Journal of Hepatolgy, in the context of alcohol-related liver injury, lipocalin 2 is associated with the development of steatohepatitis by recruiting inflammatory neutrophils to the liver.

Lipocalin 2 has been shown to be protective in a mouse model of NAFLD, but its function has not been well characterized in alcoholic steatohepatitis (ASH). The authors observed that patients with ASH had notably more lipocalin 2-positive neutrophils than patients with NAFLD or cirrhosis. The role of the protein in ASH was explored using wild-type and Lcn2−/− mice.

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References

  1. Wieser, V. et al. Lipocalin 2 drives neutrophilic inflammation in alcoholic liver disease. J. Hepatol. http://dx.doi.org/10.1016/j.jhep.2015.11.037

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Authors
  1. Gillian Patman
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Patman, G. Lipocalin 2 and steatohepatitis. Nat Rev Gastroenterol Hepatol 13, 62 (2016). https://doi.org/10.1038/nrgastro.2015.225

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