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Hepatocellular carcinoma

Working it out—exercise reduces HCC but not steatosis in mice

Nature Reviews Gastroenterology & Hepatology volume 12, page 124 (2015)Cite this article

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New research published in the Journal of Hepatology has found that in a mouse model of NASH, exercise decreases the size and incidence of hepatocellular carcinoma (HCC) without improving steatosis.

HCC is known to occur on a background of chronic liver disease, and exercise is known to be an effective treatment for patients with NAFLD. “Based on this evidence we got interested in the effects of physical activity on the risk of HCC in NASH,” explains corresponding author Jean-François Dufour.

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References

  1. Piguet, A.-C. et al. Regular exercise decreases liver tumor development in hepatocyte-specific PTEN-deficient mice independently of steatosis. J. Hepatol. 10.1016/j.jhep.2015.01.017

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Authors
  1. Gillian Patman
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Patman, G. Working it out—exercise reduces HCC but not steatosis in mice. Nat Rev Gastroenterol Hepatol 12, 124 (2015). https://doi.org/10.1038/nrgastro.2015.27

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  • DOI: https://doi.org/10.1038/nrgastro.2015.27

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