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Obesity

Mechanisms behind reduced appetite for fat after gastric bypass uncovered

Nature Reviews Gastroenterology & Hepatology volume 14, page 138 (2017)Cite this article

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New research in rats shows that decreased preference for dietary fat after Roux-en-Y gastric bypass (RYGB) stems from increased dopamine release in the dorsal striatum, mediated by greater intestinal synthesis of oleoylethanolamide (OEA) — a lipid satiety molecule and PPARα ligand — and subsequent vagus nerve signalling.

“Previous work had shown that dorsal striatal dopamine release is reduced in obesity, and that this is linked to reduced intestinal synthesis of OEA,” explains author Wiebke Fenske. “Our hypothesis was that RYGB increases meal-stimulated dorsal striatal dopamine release, via increased intestinal OEA synthesis, to reduce fat appetite”.

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References

  1. Hankir, M. K. et al. Gastric bypass surgery recruits a gut PPAR-α-striatal D1R pathway to reduce fat appetite in obese rats. Cell. Metab. http://dx.doi.org/10.1016/jcmet.2016.12.006 (2017)

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  1. Hugh Thomas
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Thomas, H. Mechanisms behind reduced appetite for fat after gastric bypass uncovered. Nat Rev Gastroenterol Hepatol 14, 138 (2017). https://doi.org/10.1038/nrgastro.2017.8

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  • DOI: https://doi.org/10.1038/nrgastro.2017.8

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