Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Dead-cell-associated proteins are an important source of antigens for cross-presentation by dendritic cells

Nature Reviews Immunology volume 4, page 656 (2004)Cite this article

A Correspondence to this article was published on 01 August 2004

Access through your institution
Buy or subscribe

Sirs

We recently had the opportunity to read the Opinion article by Matthew Albert1 that was published in Nature Reviews Immunology. Because this article is probably of interest to many scientists, we felt that it was important to bring attention to a factual error regarding one of our studies.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Albert, M. L. Death-defying immunity: do apoptotic cells influence antigen processing and presentation? Nature Rev. Immunol. 4, 223–231 (2004).

    Article  CAS  Google Scholar 

  2. Fonteneau, J. F. et al. Characterization of the MHC class I cross-presentation pathway for cell-associated antigens by human dendritic cells. Blood 102, 4448–4455 (2003).

    Article  CAS  Google Scholar 

  3. Shen, L. & Rock, K. L. Cellular protein is the source of cross-priming antigen in vivo. Proc. Natl Acad. Sci. USA 101, 3035–3040 (2004).

    Article  CAS  Google Scholar 

  4. Rodriguez, A., Regnault, A., Kleijmeer, M., Ricciardi-Castagnoli, P. & Amigorena, S. Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells. Nature Cell Biol. 1, 362–368 (1999).

    Article  CAS  Google Scholar 

  5. Arrode, G. et al. Incoming human cytomegalovirus pp65 (UL83) contained in apoptotic infected fibroblasts is cross-presented to CD8+ T cells by dendritic cells. J. Virol. 74, 10018–10024 (2000).

    Article  CAS  Google Scholar 

  6. Kotera, Y., Shimizu, K. & Mule, J. J. Comparative analysis of necrotic and apoptotic tumor cells as a source of antigen(s) in dendritic cell-based immunization. Cancer Res. 61, 8105–8109 (2001).

    CAS  PubMed  Google Scholar 

  7. Kotera, Y., Fontenot, J. D., Pecher, G., Metzgar, R. S. & Finn, O. J. Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients. Cancer Res. 54, 2856–2860 (1994).

    CAS  PubMed  Google Scholar 

  8. Larsson, M. et al. Activation of HIV-1 specific CD4+ and CD8+ T cells by human dendritic cells: roles of cross-presentation and non-infectious HIV-1 virus. AIDS 16, 1319–1329 (2002).

    Article  CAS  Google Scholar 

  9. Subklewe, M., Paludan, C., Tsang, M. L., Steinman, R. M. & Münz, C. Dendritic cells cross-present latency gene products from Epstein–Barr virus-transformed B cells and expand tumor-reactive CD8+ killer T cells. J. Exp. Med. 193, 405–412 (2001).

    Article  CAS  Google Scholar 

  10. O'Rourke, M. G. et al. Durable complete clinical responses in a phase I/II trial using an autologous melanoma cell/dendritic cell vaccine. Cancer Immunol. Immunother. 52, 387–395 (2003).

    PubMed  Google Scholar 

  11. Geiger, J. D. et al. Vaccination of pediatric solid tumor patients with tumor lysate-pulsed dendritic cells can expand specific T cells and mediate tumor regression. Cancer Res. 61, 8513–8519 (2001).

    CAS  PubMed  Google Scholar 

  12. Scheffer, S. R. et al. Apoptotic, but not necrotic, tumor cell vaccines induce a potent immune response in vivo. Int. J. Cancer 103, 205–211 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. New York University School of Medicine, 550 First Avenue, MSB 507, New York, 10016, New York, USA

    Nina Bhardwaj & Marie Larsson

Authors
  1. Nina Bhardwaj
    View author publications

    Search author on:PubMed Google Scholar

  2. Marie Larsson
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bhardwaj, N., Larsson, M. Dead-cell-associated proteins are an important source of antigens for cross-presentation by dendritic cells. Nat Rev Immunol 4, 656 (2004). https://doi.org/10.1038/nri1308-c1

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/nri1308-c1

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing