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Gene regulation

Welded on the spot

Nature Reviews Molecular Cell Biology volume 7, page 705 (2006)Cite this article

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Both groups crystallized a complex that consisted of four proteins (the DEAD-box ATPase eIF4AIII, Barentsz (Btz; also known as MLN51), Mago (or MAGOH) and Y14), an ATP analogue and RNA. The overall shape of the complex resembles an L-shaped molecule with the eIF4AIII–Btz heterodimer at the base and the Mago–Y14 heterodimer arranged almost perpendicularly to it.

eIF4AIII adopts a closed conformation with a deep interdomain cleft that buries ATP. It also binds to six RNA nucleotides on the opposite surface from the ATP-binding site, with the 3′ end interacting with domain 1 of eIF4AIII and the 5′ end interacting with domain 2. Btz also contacts the 5′ nucleotide.

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References

ORIGINAL RESEARCH PAPERS

  1. Andersen, C. B. F. et al. Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. Science 24 Aug 2006 (doi:10.1126/science.1131981)

  2. Bono, F. et al. The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA. Cell 126, 713–725 (2006)

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FURTHER READING

  1. Maquat, L. E. Nonsense-mediated mRNA decay: splicing translation and mRNP dynamics. Nature Rev. Mol. Cell Biol. 5, 89–99 (2004)

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Authors
  1. Arianne Heinrichs
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Heinrichs, A. Welded on the spot. Nat Rev Mol Cell Biol 7, 705 (2006). https://doi.org/10.1038/nrm2033

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  • DOI: https://doi.org/10.1038/nrm2033

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