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Cell migration

Chemical detectors or polarity cues?

Nature Reviews Molecular Cell Biology volume 8, page 93 (2007)Cite this article

How do cells translate the spatial information provided by chemoattractant gradients into directed cell movement?

How do cells translate the spatial information provided by chemoattractant gradients into directed cell movement? Two studies, published in Nature Cell Biology, now show the dynamic accumulation of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) at the leading edge of primary neutrophils during chemotaxis, firmly establishing an important role for PtdIns(3,4,5)P3 in chemokinesis.

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References

ORIGINAL RESEARCH PAPERS

  1. Nishio, M. et al. Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nature Cell Biol. 9, 36–44 (2007)

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  2. Ferguson, G. J. et al. PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis. Nature Cell Biol. 9, 86–91 (2007)

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FURTHER READING

  1. Franca-Koh, J., Kamimura, Y. & Devreotes, P. N. Leading-edge research: PtdIns(3,4,5)P3 and directed migration. Nature Cell Biol. 9, 15–17 (2007)

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Authors
  1. Ekat Kritikou
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Kritikou, E. Chemical detectors or polarity cues?. Nat Rev Mol Cell Biol 8, 93 (2007). https://doi.org/10.1038/nrm2111

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  • DOI: https://doi.org/10.1038/nrm2111

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