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A distinct human signature

Nature Reviews Molecular Cell Biology volume 8, page 182 (2007)Cite this article

A distinct chromatin modification — trimethylation of Lys4 in histone H3 — marks gene promoters, whereas monomethylation of the same residue identifies enhancers, reports a Nature Genetics paper.

Previous work has shown that modified histone modifications are associated with transcription-associated regulatory elements. In yeast, flies and mice, active promoters are often marked by trimethylation of a Lys residue in histone H3. Now, Bing Ren and colleagues at the University of California, San Diego, USA, looked systematically for this mark in the human genome.

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  1. Ekat Kritikou
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Kritikou, E. A distinct human signature. Nat Rev Mol Cell Biol 8, 182 (2007). https://doi.org/10.1038/nrm2131

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