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Mechanisms of disease

Kinases out of control — brake line cut!

Nature Reviews Molecular Cell Biology volume 8, page 854 (2007)Cite this article

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Previous patient screenings had uncovered several pathogenic mutations in the RTK fibroblast growth-factor receptor-2 (FGFR2). Measuring the intrinsic kinase activity of several pathogenic FGFR2 mutants, Chen and colleagues found that several of these mutations conferred higher rates of activation (A) loop autophosphorylation and peptide substrate phosphorylation.

... a triad of residues makes up a molecular brake that inhibits RTK activation.

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ORIGINAL RESEARCH PAPER

  1. Chen, H. et al. A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol. Cell 27, 717–730 (2007)

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  1. Asher Mullard
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Mullard, A. Kinases out of control — brake line cut!. Nat Rev Mol Cell Biol 8, 854 (2007). https://doi.org/10.1038/nrm2280

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