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Endocytosis

A new way to hijack the cell

Nature Reviews Molecular Cell Biology volume 9, page 2 (2008)Cite this article

In Nature, Johannes and co-workers report an alternative mechanism of CI endocytosis, and show that the B-subunit of the bacterial Shiga toxin (STxB) — which binds the glycosphingolipid receptor globotriaosyl ceramide (Gb3) — can induce the formation of narrow tubular invaginations on the plasma membrane of target cells without the need for cytosolic factors.

...STxB could induce the formation of inward tubules...

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References

ORIGINAL RESEARCH PAPER

  1. Römer, W. et al. Shiga toxin induces tubular membrane invaginations for its uptake into cells. Nature 450, 670–675 (2007)

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FURTHER READING

  1. Mayor, S. and Pagano, R. E. Pathways of clathrin-independent endocytosis. Nature Rev. Mol. Cell Biol. 8, 603–612 (2007)

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Authors
  1. Francesca Cesari
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Ludger Johannes's laboratory

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Cesari, F. A new way to hijack the cell. Nat Rev Mol Cell Biol 9, 2 (2008). https://doi.org/10.1038/nrm2318

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