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Chromosome segregation

Tension rules

Nature Reviews Molecular Cell Biology volume 9, page 95 (2008)Cite this article

...shugoshins are involved in all instances of centromeric cohesion protection...

Meiosis is a specialized type of cell division that generates non-identical haploid gametes from diploid progenitor cells. This is achieved by a single round of DNA replication followed by two chromosome segregation phases: segregation of the homologues (meiosis I) is followed by the dissolution of centromere cohesion and the segregation of sister chromatids (meiosis II). Previous studies in yeast have shown that shugoshin associates with protein phosphatase-2A (PP2A) throughout meiosis I and prevents phosphorylation of centromeric cohesin — a multiprotein complex that maintains tight association of sister chromatids. This prevents cleavage of cohesin by the protease separase and subsequent sister chromatid separation.

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References

ORIGINAL RESEARCH PAPER

  1. Lee, J. et al. Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells. Nature Cell Biol. 16 Dec 2007 (doi:10.1038/ncb1667)

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FURTHER READING

  1. Marston, A. L. & Amon, A. Meiosis: cell-cycle controls shuffle and deal. Nature Rev. Mol. Cell Biol. 5, 983–997 (2004)

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Authors
  1. Francesca Cesari
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Cesari, F. Tension rules. Nat Rev Mol Cell Biol 9, 95 (2008). https://doi.org/10.1038/nrm2331

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  • DOI: https://doi.org/10.1038/nrm2331

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