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Cell migration

Cells go A-B-C

Nature Reviews Molecular Cell Biology volume 10, page 237 (2009)Cite this article

Ruth Lehmann and co-workers have previously shown that Drosophila melanogaster germ cells fail to migrate to the somatic gonad in the mesoderm in embryos that lack 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) — an enzyme that adds geranylgeranyl moieties to the carboxyl termini of peptides. Notably, the expression of HMGCR in other cell types is sufficient to attract germ cells to a new location.

“...[ABC] transporters export lipid-modified peptides that are essential for directed cell migration.”

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References

ORIGINAL RESEARCH PAPERS

  1. Ricardo, S. & Lehmann, R. An ABC transporter controls export of a Drosophila germ cell attractant. Science 323, 943–946 (2009)

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  2. Kawahara, A. et al. The sphingolipid transporter Spns2 functions in migration of zebrafish myocardial precursors. Science 323, 524–527 (2009)

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FURTHER READING

  1. Rees, D. C. et al. ABC transporters: the power to change. Nature Rev. Mol. Cell Biol. 10, 218–227 (2009)

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  2. Kay, R. R. et al. Changing directions in the study of chemotaxis. Nature Rev. Mol. Cell Biol. 9, 455–463 (2008)

    Article  CAS  Google Scholar 

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Authors
  1. Francesca Cesari
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Cesari, F. Cells go A-B-C. Nat Rev Mol Cell Biol 10, 237 (2009). https://doi.org/10.1038/nrm2658

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