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Autophagy

Autophagy takes an alternative route

Nature Reviews Molecular Cell Biology volume 10, page 735 (2009)Cite this article

“an ATG5- and ATG7- independent pathway that controls autophagy.”

Nishida et al. observed autophagic structures, such as autophagosomes (double membrane-bound vesicles that sequester materials to be degraded and deliver them to lysosomes), in Atg5−/− and in Atg7−/− mouse embryonic fibroblasts (MEFs) that were treated with etoposide (a cellular stress-inducing agent) or starved. This suggests that an ATG5- and ATG7-independent autophagy system exists.

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References

ORIGINAL RESEARCH PAPER

  1. Nishida, Y. et al. Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature 461, 654–658 (2009)

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FURTHER READING

  1. Nakatogawa, H. et al. Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nature Rev. Mol. Cell Biol. 10, 458–467 (2009)

    Article  CAS  Google Scholar 

  2. Kroemer, G. & Levine, B. Autophagic cell death: the story of a misnomer. Nature Rev. Mol. Cell Biol. 9, 1004–1010 (2008)

    Article  CAS  Google Scholar 

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Authors
  1. Francesca Cesari
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Cesari, F. Autophagy takes an alternative route. Nat Rev Mol Cell Biol 10, 735 (2009). https://doi.org/10.1038/nrm2790

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