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DNA replication

Cohesin on the fork

Nature Reviews Molecular Cell Biology volume 10, page 814 (2009)Cite this article

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Sister chromatid cohesion ensures proper chromosome segregation and is mediated by the cohesin complex forming a ring around sister chromatids. How DNA replication forks go through cohesin-associated obstructions to achieve genome replication remains unclear. Prasad Jallepalli and colleagues now report that fork advancement depends on cohesin acetylation, which might affect cohesin conformation.

As cells expressing non-acetylatable SMC3 also show loss of cohesion, the authors investigated whether cohesin acetylation requires RFCCTF18. Indeed, RFCCTF18-deficient cells showed a 70% reduction of SMC3 acetylation. RFCCTF18 thus affects both replication fork processivity and cohesin acetylation, but are these processes linked?

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References

ORIGINAL RESEARCH PAPER

  1. Terret, M. -E. et al. Cohesin acetylation speeds the replication fork. Nature 12 Nov 2009 (doi: 10.1038/nature08550)

FURTHER READING

  1. Yanagida, M. Clearing the way for mitosis: is cohesin a target? Nature Rev. Mol. Cell Biol. 10, 489–496 (2009)

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Authors
  1. Kim Baumann
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Baumann, K. Cohesin on the fork. Nat Rev Mol Cell Biol 10, 814 (2009). https://doi.org/10.1038/nrm2810

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  • DOI: https://doi.org/10.1038/nrm2810

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