This year p53 celebrates 30 years of research. We mark this occasion with a Poster highlighting some of the key discoveries that have led to our current understanding of p53 as a tumour suppressor that regulates many important biological activities, and is itself regulated by various post-translational modifications. This Poster, by Bert Vogelstein and Carol Prives, (www.nature.com/reviews/posters/p53) was produced by Nature Reviews Molecular Cell Biology and Nature Reviews Cancer, with generous support from Roche Molecular Systems and Genentech.
This issue also includes the last of our Darwin 200 articles, which were specially commissioned this year as part of a NPG wide celebration of the bicentenary of Charles Darwin's birth and the 150th anniversary of the publication of On the Origin of Species by Means of Natural Selection. The Review by Philip A. Romero and Frances H. Arnold (page 866) describes how directed evolution adapts and optimizes protein function through successive generations of random mutation, artificial selection and screening. Also on the theme of adapting protein behaviour, Stefanie L. Ritter and Randy A. Hall (page 819) describe how the signalling and trafficking properties of G protein-coupled receptors can be fine-tuned by receptor-interacting proteins that are differentially expressed in distinct cell types.
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