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Circadian rhythms

PARP1 feeds into clocks

Nature Reviews Molecular Cell Biology volume 11, page 755 (2010)Cite this article

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Cellular levels of the metabolite NAD+/NADH oscillate daily and regulate other enzymes that are important for clock control. Asher et al. therefore asked whether another NAD+-dependent enzyme, PARP1, might also be important for circadian functions. They found that PARP1 activity in the mouse liver is rhythmic and that the peak of this activity can be altered by changes in feeding patterns.

PARP1 participates in linking circadian oscillators to metabolic cues

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References

ORIGINAL RESEARCH PAPER

  1. Asher, G. et al. Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell 142, 943–953 (2010)Article

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FURTHER READING

  1. Zhang, E. E. & Kay, S. A. Clocks not winding down: unravelling circadian networks. Nature Rev. Mol. Cell Biol. 11, 764–766 (2010)

    Article  CAS  Google Scholar 

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Authors
  1. Alison Schuldt
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Schuldt, A. PARP1 feeds into clocks. Nat Rev Mol Cell Biol 11, 755 (2010). https://doi.org/10.1038/nrm2998

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