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Oxidative stress

ATM bonds under stress

Nature Reviews Molecular Cell Biology volume 11, page 819 (2010)Cite this article

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In response to DNA damage, non-covalently associated dimeric ATM is converted to an active monomer by the MRE11A–RAD50–NBS1 (MRN) DNA repair complex. ATM then phosphorylates proteins that initiate activation of the DNA damage response, including p53 and Ser/Thr-protein kinase CHK2. In a twist of this general scheme, the authors show that oxidative stress-mediated activation of ATM is independent of the MRN complex and affects only a subset of the ATM targets that are induced downstream of DNA damage.

a novel pathway for ATM activation and ... evidence that ATM acts as an oxygen sensor in human cells.

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References

ORIGINAL RESEARCH PAPER

  1. Guo, Z. et al. ATM activation by oxidative stress. Science 330, 517–521 (2010) Article

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FURTHER READING

  1. Lanvin, M. F. Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer. Nature Rev. Mol. Cell Biol. 9, 759–769 (2008)

    Article  Google Scholar 

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  1. Consulting Editor, NCI–Nature Pathway Interaction Database,

    Mhairi Skinner

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  1. Mhairi Skinner
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Skinner, M. ATM bonds under stress. Nat Rev Mol Cell Biol 11, 819 (2010). https://doi.org/10.1038/nrm3017

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