Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Protein synthesis

An expressive couple

Nature Reviews Molecular Cell Biology volume 12, page 8 (2011)Cite this article

Subjects

mRNAs shuttle between polysomes (sites of active translation) and processing bodies (PBs), the latter being complexes in which non-translating mRNAs accumulate and may be degraded. It is increasingly evident that translation and mRNA decay are intimately coupled and coordinately regulated. Transcription has also been linked to mRNA decay, as the co-transcriptional association between Rpb4–Rpb7 and mRNA regulates two major mRNA decay pathways.

These investigations have revealed a new link between transcription and translation that is mediated by Rpb4—Rpb7.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

ORIGINAL RESEARCH PAPER

  1. Harel-Sharvit, L. et al. RNA polymerase II subunits link transcription and mRNA decay to translation. Cell 143, 552–563 (2010)

    Article  CAS  Google Scholar 

FURTHER READING

  1. Jackson, R. J., Hellen, C. U. T. & Pestova, T. V. The mechanism of eukaryotic translation initiation and principles of its regulation. Nature Rev. Mol. Cell Biol. 11, 113–127 (2010)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Consulting Editor NCI–Nature ,

    Mhairi Skinner

Authors
  1. Mhairi Skinner
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Skinner, M. An expressive couple. Nat Rev Mol Cell Biol 12, 8 (2011). https://doi.org/10.1038/nrm3037

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrm3037

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing