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Cell signalling

PRMT5 restricts ERK activity

Nature Reviews Molecular Cell Biology volume 12, page 689 (2011)Cite this article

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a PRMT5-induced methylation event can decrease the amplitude of ERK phosphorylation.

The authors observed that cellular ERK1 and ERK2 phosphorylation increase in response to several growth factors in the presence of the methylation inhibitor 5′-methylthioadenosine (MTA). Depletion of the methyltransferase PRMT5 also increased growth factor-induced ERK phosphorylation, suggesting that a PRMT5-induced methylation event can decrease the amplitude of ERK phosphorylation.

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ORIGINAL RESEARCH PAPER

  1. Andreu-Pérez, P. et al. Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF. Sci. Signal. 4, ra58 (2011)

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  1. Katharine H. Wrighton
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Wrighton, K. PRMT5 restricts ERK activity. Nat Rev Mol Cell Biol 12, 689 (2011). https://doi.org/10.1038/nrm3213

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