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Plant cell biology

Sensing oxygen

Nature Reviews Molecular Cell Biology volume 12, page 770 (2011)Cite this article

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An Erratum to this article was published on 30 November 2011

This article has been updated

Proteins carrying particular amino-terminal sequences (known as N degrons) can be targeted for proteasomal degradation via the N-end rule pathway, following Arg conjugation by the Arg transferase ATE and subsequent ubiquitylation by the ligase PROTEOLYSIS 6 (PRT6). Gibbs et al. found that ate and prt6 mutant seedlings constitutively expressed genes important for anaerobic metabolism and hypoxia at high levels, and were more resistant to long-term oxygen deprivation. Licausi et al. also showed that ate and prt6 mutants had altered hypoxia responses, which demonstrates a link between the N-end rule pathway and the response to hypoxia.

group VII ERFs are substrates of the N-end rule pathway and sense oxygen levels

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Change history

  • 30 November 2011

    There was an error in the definition of ERF: "EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR" should have read "ETHYLENE RESPONSE FACTOR". This has been corrected Online.

References

ORIGINAL RESEARCH PAPERS

  1. Gibbs, D. J. et al. Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants. Nature 23 Oct 2011 (doi:10.1038/nature10534)

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  2. Licausi, F. et al. Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization. Nature 23 Oct 2011 (doi:10.1038/nature10536)

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FURTHER READING

  1. Sriram, S. M., Kim, B. Y. & Kwon, Y. T. The N-end rule pathway: emerging functions and molecular principles of substrate recognition. Nature Rev. Mol. Cell Biol. 12, 735–747 (2011)

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Authors
  1. Kim Baumann
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Baumann, K. Sensing oxygen. Nat Rev Mol Cell Biol 12, 770 (2011). https://doi.org/10.1038/nrm3235

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