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Cell signalling

Hedgehog puts a damper on autophagy

Nature Reviews Molecular Cell Biology volume 14, page 3 (2013)Cite this article

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To determine whether Hedgehog signalling plays a part in autophagy, the authors investigated the effects of Hedgehog agonists. First, they showed that Hedgehog peptides reduced autophagosome numbers (as measured by decreased levels of LC3-II, a marker of autophagosomes) and decreased protein clearance in cultured mammalian cells compared with untreated cells. This inhibitory effect was also observed when autophagy was induced by starvation or rapamycin, suggesting that Hedgehog signalling impairs autophagy in both basal and induced conditions.

autophagy is impaired by canonical Hedgehog signalling

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ORIGINAL RESEARCH PAPER

  1. Jimenez-Sanchez, M. et al. The Hedgehog signalling pathway regulates autophagy. Nature Commun. 13 Nov 2012 (doi:10.1038/ncomms2212)

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  1. Andrea Du Toit
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Du Toit, A. Hedgehog puts a damper on autophagy. Nat Rev Mol Cell Biol 14, 3 (2013). https://doi.org/10.1038/nrm3487

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