Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Cell signalling

Limiting the side effects of senescence

Nature Reviews Molecular Cell Biology volume 16, page 451 (2015)Cite this article

Subjects

Access through your institution
Buy or subscribe

by enhancing the translation of the cell surface-bound cytokine interleukin-1α (IL-1α), mTOR promotes the senescence-associated secretory phenotype

The SASP is a major feature of senescent cells and involves the secretion of cytokines, growth factors and proteases. Cellular senescence, which is a state of permanent cell cycle arrest, usually inhibits tumorigenesis, as it prevents the proliferation of potential cancer cells. However, as senescent cells accumulate with age, persistent inflammation associated with the SASP can be damaging for tissues and can also contribute to cancer progression.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Laberge, R.-M. et al. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat. Cell Biol. http://dx.doi.org/10.1038/ncb3195 (2015)

Download references

Authors
  1. Kim Baumann
    View author publications

    Search author on:PubMed Google Scholar

Related links

Related links

Related links in Nature Research

Muñoz-Espín, D. & Serrano, M. Cellular senescence: from physiology to pathology. Nat. Rev. Mol. Cell Biol. 15, 482–496 (2014)

Zoncu, R., Efeyan, A. & Sabatini, D. M. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 12, 21–35 (2010)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Baumann, K. Limiting the side effects of senescence. Nat Rev Mol Cell Biol 16, 451 (2015). https://doi.org/10.1038/nrm4030

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrm4030

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer