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Innate immunity

Pick a CARD

Nature Reviews Microbiology volume 4, pages 720–721 (2006)Cite this article

The innate immune system of vertebrates detects pathogenic organisms by recognizing the molecular patterns typical of microbial components. Toll-like receptors (TLRs) constitute a major class of pattern-recognition receptors (PRRs), but other PRRs are also important for the recognition of certain pathogens. However, the way in which these PRRs trigger inflammatory pathways is not well understood. A recent study of the poorly characterized protein caspase-recruitment-domain protein 9 (CARD9) has helped to delineate a novel non-TLR-dependent signalling pathway involved in antifungal innate immunity.

CARD9 is structurally related to CARD–MAGUK (membrane-associated guanylate kinase) protein 1 (CARMA1). CARMA1 mediates nuclear factor-κB (NF-κB) activation through BCL-10 (B-cell lymphoma 10) and MALT1 (mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1) in response to the activation of T- and B-cell receptors. CARD9 can bind BCL-10 but lacks other regions that are typical of CARMA family members involved in NF-κB activation. Given these characteristics, it was thought that CARD9 might interfere with the interaction between CARMA1 and BCL-10.

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ORIGINAL RESEARCH PAPER

  1. Gross, O. et al. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 442, 651–656 (2006)

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Authors
  1. Edward Wawrzynczak
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Wawrzynczak, E. Pick a CARD. Nat Rev Microbiol 4, 720–721 (2006). https://doi.org/10.1038/nrmicro1516

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  • DOI: https://doi.org/10.1038/nrmicro1516

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