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New TB drug cocktail

Nature Reviews Microbiology volume 10, page 594 (2012)Cite this article

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The development of novel combination therapies is one of several strategies that are currently being pursued to combat tuberculosis (TB). Recently, researchers at the XIX International AIDS Conference presented the results of a groundbreaking clinical trial which showed that a combination of three drugs can kill more than 99% of Mycobacterium tuberculosis in infected patients.

The 2-week trial, the results of which were published in The Lancet, assessed the bactericidal activity of three drugs administered together, two of which have not yet received US FDA approval for TB treatment. This new cocktail, termed PaMZ, consisted of the novel drug candidate PA-284, the antibiotic moxifloxacin and the existing TB drug pyrazinamide. The results indicate that PaMZ not only is more effective than current treatments, but also could substantially shorten drug regimens and is potentially active against multidrug-resistant infections.

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  1. Christina Tobin Kåhrström
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Kåhrström, C. New TB drug cocktail. Nat Rev Microbiol 10, 594 (2012). https://doi.org/10.1038/nrmicro2864

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