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Parasite biology

PINning down Theileria

Nature Reviews Microbiology volume 13, page 127 (2015)Cite this article

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To identify proteins secreted by Theileria spp. that could contribute to host cell transformation, the authors carried out an in silico screen of parasite genomes to search for genes encoding signal peptides that are specific to the Theileria genus. This screen identified 33 candidate genes, one of which encoded a homologue of human parvulin PIN1 (hPIN1), which is a PPIase that is associated with tumorigenesis in humans. Confocal microscopy showed that T. annulata PIN1 (TaPIN1) is secreted into the cytoplasm and nucleus of host cells, and a combination of in vitro and in vivo assays confirmed that it is an active PPIase with an ability to transform bovine leukocytes.

TaPIN1 promotes oncogenesis by binding to and destabilizing FBW7

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References

  1. Marsolier, J. et al. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Nature http://dx.doi.org/10.1038/nature14044 (2015)

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  1. Naomi Attar
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Attar, N. PINning down Theileria. Nat Rev Microbiol 13, 127 (2015). https://doi.org/10.1038/nrmicro3444

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